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Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population

Palka Kaur Khanuja,Satish Chander Narula,Rajesh Rajput,Rajinder Kumar Sharma,Shikha Tewari

Frontiers of Medicine 2017, Volume 11, Issue 1,   Pages 110-119 doi: 10.1007/s11684-016-0484-5

Abstract: A total of 207 patients with type 2 diabetes and chronic periodontitis (CP) were divided according toanalyses were carried out for glycated hemoglobin (HbA1c), fasting plasma glucose (FPG), 2After controlling for age, gender, body mass index (BMI), socioeconomic status (SES), family history of diabetesand periodontitis, duration of diabetes, the mean PISA in mm2, PPD 4--6 mm (%) and PPD&ge

Keywords： type 2 diabetes mellitus     hemoglobin A     glycated     chronic periodontitis    

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Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetesmellitus: a cross-sectional cohort study

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Frontiers of Medicine 2020, Volume 14, Issue 5,   Pages 642-650 doi: 10.1007/s11684-019-0719-3

Abstract: correlation between serum miR-154-5p and urinary albumin to creatinine ratio (UACR) in patients with type2 diabetes mellitus (T2DM) and the association with biomarkers of inflammation and fibrosis in diabeticA total of 390 patients with T2DM were divided into three groups: normal albuminuria (UACR<30 mg/g,via real-time PCR, enzyme-linked immunosorbent assay, and chemiluminescence assay in patients with T2DMindicated that elevated serum miR-154-5p is significantly correlated with high UACR in patients with T2DM

Keywords： type 2 diabetes mellitus     diabetic kidney disease     miR-154-5p     urinary albumin to creatinine ratio    

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New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 17-24 doi: 10.1007/s11684-021-0873-2

Abstract: Obesity is an important risk factor of type 2 diabetes (T2D), which has become an important factor threateningThis review summarizes clinical evidence of the semaglutide effect on T2D and obesity and establishes

Keywords： semaglutide     type 2 diabetes     obesity    

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evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Frontiers of Medicine 2014, Volume 8, Issue 4,   Pages 471-476 doi: 10.1007/s11684-014-0365-8

Abstract: weighted imaging (DWI) and diffusion tensor imaging (DTI) in detecting early-stage kidney injury in type2 diabetic patients with normoalbuminuria (NAU) versus microalbuminuria (MAU) prospectively.A total of 30 T2DM patients with normal kidney function were recruited and assigned to the NAU groupAccording to DWI with a b value of 400 s/mm2, the MAU and NAU groups showedThe mean ADC in the MAU group [(2.22±0.07)×10–3 mm2/s]

Keywords： type 2 diabetes mellitus     microalbuminuria     diffusion weighted imaging     diffusion tensor imaging     early-stage    

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Cytokines and inflammation in adipogenesis: an updated review

Ning Jiang, Yao Li, Ting Shu, Jing Wang

Frontiers of Medicine 2019, Volume 13, Issue 3,   Pages 314-329 doi: 10.1007/s11684-018-0625-0

Abstract: The biological relevance of cytokines is known for more than 20 years. Evidence suggests that adipogenesis is one of the biological events involved in the regulation of cytokines, and pro-inflammatory cytokines (e.g., TNF and IL-1 ) inhibit adipogenesis through various pathways. This inhibitory effect can constrain the hyperplastic expandability of adipose tissues. Meanwhile, chronic low-grade inflammation is commonly observed in obese populations. In some individuals, the impaired ability of adipose tissues to recruit new adipocytes to adipose depots during overnutrition results in adipocyte hypertrophy, ectopic lipid accumulation, and insulin resistance. Intervention studies showed that pro-inflammatory cytokine antagonists improve metabolism in patients with metabolic syndrome. This review focuses on the cytokines currently known to regulate adipogenesis under physiological and pathophysiological circumstances. Recent studies on how inhibited adipogenesis leads to metabolic disorders were summarized. Although the interplay of cytokines and lipid metabolism is yet incompletely understood, cytokines represent a class of potential therapeutic targets in the treatment of metabolic disorders.

Keywords： cytokines     inflammation     adipogenesis     type 2 diabetes mellitus     metabolic disorder    

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Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 288-293 doi: 10.1007/s11684-011-0127-9

Abstract: Haemorheological abnormalities have been described in diabetes mellitus, as well as in non-alcoholiccorrelation between haemorheological parameters and intrahepatic lipid content (IHLC) in patients with type2 diabetes.In summary, haemorheological disorders are linked to non-alcoholic fatty liver in type 2 diabetes.

Keywords： diabetes mellitus     type 2     haemorheology     non-alcoholic fatty liver disease    

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Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 4-13 doi: 10.1007/s11684-013-0248-4

Abstract:

The high prevalence of diabetes and diabetic complications has caused a huge burden on the modernAlthough scientific advances have led to effective strategies for preventing and treating diabetes overThere is still a lack of reliable biomarkers indicative of metabolic alterations associated with diabetesRecent studies using metabolomics approach coupled with statistical tools to predict incident diabetes, type 2 diabetes.

Keywords： metabolomics     type 2 diabetes     metabolic pathway     mass spectrometry     nuclear magnetic resonance (NMR)    

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Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai

Frontiers of Medicine 2022, Volume 16, Issue 1,   Pages 126-138 doi: 10.1007/s11684-021-0897-7

Abstract: This cross-sectional study aimed to investigate the quality of care of diabetes in Shanghai, China.A total of 173 235 patients with type 2 diabetes in 2017 were included in the analysis.The patients had a mean age of 66.43±8.12 (standard deviation (SD)) years and a mean diabetes durationfactors associated with a great likelihood of achieving all three target levels: male, young age, short diabetesIn conclusion, nearly 50% and one-third of the patients with diabetes met the target levels for HbA

Keywords： type 2 diabetes     quality of care     macrovascular complication     microvascular complication     treatment pattern    

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Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua JIANG, Zhibo HAN, Guangsheng ZHUO, Xiaodan QU, Xue LI, Xin WANG, Yuankang SHAO, Shimin YANG, Zhong Chao HAN

Frontiers of Medicine 2011, Volume 5, Issue 1,   Pages 94-100 doi: 10.1007/s11684-011-0116-z

Abstract:

Mesenchymal stem cells (MSC) have been used in clinical trials for severe diabetes, a chronic diseaseHere, the therapeutic effect of human placenta-derived MSC (PD-MSC) was studied in type 2 diabetes patientspoor glycemic control in order to evaluate the safety, efficacy and feasibility of PD-MSC treatment in type2 diabetes (T2D).Ten patients with T2D received three intravenous infusions of PDSC, with one month interval of infusion

Keywords： placenta stem cells     treatment of type 2 diabetes    

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From gut changes to type 2 diabetes remission after gastric bypass surgeries

Bing Li, Xinrong Zhou, Jiarui Wu, Huarong Zhou

Frontiers of Medicine 2013, Volume 7, Issue 2,   Pages 191-200 doi: 10.1007/s11684-013-0258-2

Abstract: suggests that the gut may influence the host’s metabolism and ultimately change the outcomes of type2 diabetes mellitus (T2DM).We review the evidence on the relationship between the gut and T2DM remission after gastric bypass surgeryElucidating the precise metabolic mechanisms of T2DM resolution after bypass surgery will help to reveal

Keywords： gastric bypass     T2DM     gut    

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Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes

SUN Mingxiao, WANG Yao, CHI Jiamin

Frontiers of Medicine 2008, Volume 2, Issue 2,   Pages 174-177 doi: 10.1007/s11684-008-0032-z

Abstract: modulatory effect of on dyslipidemia and the preventive effect on atherosclerosis in newly diagnosed type2 diabetic patients were studied.prospective clinical trial was conducted to test the effectiveness of in selected 201 newly diagnosed type2 diabetic patients.2 diabetes patients, and may be related with the improvement of early atherosclerosis.
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The mechanisms linking adiposopathy to type 2 diabetes

Jichun Yang, Jihong Kang, Youfei Guan

Frontiers of Medicine 2013, Volume 7, Issue 4,   Pages 433-444 doi: 10.1007/s11684-013-0288-9

Abstract: Adiposopathy is an independent risk factor for many diseases, including diabetes and cardiovascular diseasespancreatic β cell dysfunction and liver insulin resistance, which are the decisive factors causing type2 diabetes.regarding the effects of adiposopathy-related lipotoxicity and cytokine toxicity on the development of type2 diabetes.

Keywords： obesity     adiposopathy     lipotoxicity     adipokines     diabetes    

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Traditional Chinese Medicine-Based Subtyping of Early-Stage Type 2 Diabetes Using Plasma Metabolomics Article

Min He, Mengmeng Sun, Slavik Koval, Roeland Van Wijk, Thomas Hankemeier, Jan Van der Greef, Eduard P.A. Van Wijk, Mei Wang

Engineering 2019, Volume 5, Issue 5,   Pages 916-923 doi: 10.1016/j.eng.2019.03.011

Abstract:

The prevalence of type 2 diabetes mellitus (T2DM) is increasing rapidly worldwide.Principal component analysis of plasma metabolites revealed differences among the TCM-based pre-T2DMthe lipid profile is an essential component captured by UPE with respect to stratifying subtypes of T2DMThe results suggest that metabolic differences exist among different TCM-based subtypes of pre-T2DM,

Keywords： Type 2 diabetes mellitus     Plasma metabolites     Disease subtypes     Ultra-weak photon emission     Correlation    

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Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis

Liping Xuan, Zhiyun Zhao, Xu Jia, Yanan Hou, Tiange Wang, Mian Li, Jieli Lu, Yu Xu, Yuhong Chen, Lu Qi, Weiqing Wang, Yufang Bi, Min Xu

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 678-687 doi: 10.1007/s11684-018-0671-7

Abstract:

Type 2 diabetes (T2D) has been associated with a high prevalence of depression.aimed to determine the causal relation by performing a Mendelian randomization (MR) study using 34 T2DThe T2D genetic risk score (GRS) was built using the 34 typical T2D common variants.We used T2D_GRS as the IV estimator and performed inverse-variance weighted (IVW) and Egger MR analysisUsing T2D_GRS as the IV, we similarly found a causal relationship between genetically determined T2D

Keywords： causal modeling     depression     Mendelian randomization     type 2 diabetes    

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Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 688-696 doi: 10.1007/s11684-018-0662-8

Abstract:

Xiao Ke Qing (XKQ) granule has been clinically used to treat type 2 diabetes mellitus (T2DM) for 10This study aims to investigate XKQ mechanisms on diabetes and diabetic liver disease by using the KKAyXKQ is an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signaling

Keywords： XKQ     type 2 diabetes mellitus     KKAy mice     PI3K/Akt pathway     diabetic liver disease    

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Title Author Date Type Operation

Association of periodontal disease with glycemic control in patients with type 2 diabetes in Indian population

Palka Kaur Khanuja,Satish Chander Narula,Rajesh Rajput,Rajinder Kumar Sharma,Shikha Tewari

Journal Article

Correlation between serum miR-154-5p and urinary albumin excretion rates in patients with type 2 diabetesmellitus: a cross-sectional cohort study

Huiwen Ren, Can Wu, Ying Shao, Shuang Liu, Yang Zhou, Qiuyue Wang

Journal Article

New practice in semaglutide on type-2 diabetes and obesity: clinical evidence and expectation

Journal Article

evaluation of renal function using diffusion weighted imaging and diffusion tensor imaging in type 2

Xiaoyan Chen,Wenxia Xiao,Xinchun Li,Jianxun He,Xiaochun Huang,Yuyu Tan

Journal Article

Cytokines and inflammation in adipogenesis: an updated review

Ning Jiang, Yao Li, Ting Shu, Jing Wang

Journal Article

Type 2 diabetic patients with non-alcoholic fatty liver disease exhibit significant haemorheological

Hui Dong, Fu’er Lu, Nan Wang, Xin Zou, Jingjing Rao

Journal Article

Metabolomics in human type 2 diabetes research

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Effectiveness of quality of care for patients with type 2 diabetes in China: findings from the Shanghai

Journal Article

Transplantation of placenta-derived mesenchymal stem cells in type 2 diabetes: a pilot study

Ranhua JIANG, Zhibo HAN, Guangsheng ZHUO, Xiaodan QU, Xue LI, Xin WANG, Yuankang SHAO, Shimin YANG, Zhong Chao HAN

Journal Article

From gut changes to type 2 diabetes remission after gastric bypass surgeries

Bing Li, Xinrong Zhou, Jiarui Wu, Huarong Zhou

Journal Article

Modulatory effect on dyslipidemia and anti-atherosclerotic function of in newly diagnosed type 2 diabetes

SUN Mingxiao, WANG Yao, CHI Jiamin

Journal Article

The mechanisms linking adiposopathy to type 2 diabetes

Jichun Yang, Jihong Kang, Youfei Guan

Journal Article

Traditional Chinese Medicine-Based Subtyping of Early-Stage Type 2 Diabetes Using Plasma Metabolomics

Min He, Mengmeng Sun, Slavik Koval, Roeland Van Wijk, Thomas Hankemeier, Jan Van der Greef, Eduard P.A. Van Wijk, Mei Wang

Journal Article

Type 2 diabetes is causally associated with depression: a Mendelian randomization analysis

Liping Xuan, Zhiyun Zhao, Xu Jia, Yanan Hou, Tiange Wang, Mian Li, Jieli Lu, Yu Xu, Yuhong Chen, Lu Qi, Weiqing Wang, Yufang Bi, Min Xu

Journal Article

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway in KKAy mice

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Journal Article